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arXiv · 2501.18223

Exploring Large Protein Language Models in Constrained Evaluation Scenarios within the FLIP Benchmark

Manuel F. Mollon·Joaquin Gonzalez-Rodriguez·Alicia Lozano-Diez·Daniel Ramos·Doroteo T. Toledano
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Abstract

In this study, we expand upon the FLIP benchmark-designed for evaluating protein fitness prediction models in small, specialized prediction tasks-by assessing the performance of state-of-the-art large protein language models, including ESM-2 and SaProt on the FLIP dataset. Unlike larger, more diverse benchmarks such as ProteinGym, which cover a broad spectrum of tasks, FLIP focuses on constrained settings where data availability is limited. This makes it an ideal framework to evaluate model performance in scenarios with scarce task-specific data. We investigate whether recent advances in protein language models lead to significant improvements in such settings. Our findings provide valuable insights into the performance of large-scale models in specialized protein prediction tasks.

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Manuel F. Mollon, Joaquin Gonzalez-Rodriguez, Alicia Lozano-Diez, Daniel Ramos, Doroteo T. Toledano. 2025-01-30. Exploring Large Protein Language Models in Constrained Evaluation Scenarios within the FLIP Benchmark. https://arxiv.org/abs/2501.18223

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