Predictive Information Decomposition as a Tool to Quantify Emergent Dynamical Behaviors In Physiological Networks

Abstract

Objective: This work introduces a framework for multivariate time series analysis aimed at detecting and quantifying collective emerging behaviors in the dynamics of physiological networks. Methods: Given a network system mapped by a vector random process, we compute the predictive information (PI) between the present and past network states and dissect it into amounts quantifying the unique, redundant and synergistic information shared by the present of the network and the past of each unit. Emergence is then quantified as the prevalence of the synergistic over the redundant contribution. The framework is implemented in practice using vector autoregressive (VAR) models. Results: Validation in simulated VAR processes documents that emerging behaviors arise in networks where multiple causal interactions coexist with internal dynamics. The application to cardiovascular and respiratory networks mapping the beat-to-beat variability of heart rate, arterial pressure and respiration measured at rest and during postural stress reveals the presence of statistically significant net synergy, as well as its modulation with sympathetic nervous system activation. Conclusion: Causal emergence can be efficiently assessed decomposing the PI of network systems via VAR models applied to multivariate time series. This approach evidences the synergy/redundancy balance as a hallmark of integrated short-term autonomic control in cardiovascular and respiratory networks. Significance: Measures of causal emergence provide a practical tool to quantify the mechanisms of causal influence that determine the dynamic state of cardiovascular and neural network systems across distinct physiopathological conditions.