Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 2505.06412

Cross-Domain Transfer of Depression Voice Biomarkers Depends on the Outcome Instrument: Leakage-Controlled Cross-Sectional Evaluation Study

Rachel L. Wiley·Jim Schwoebel·Joel Shor·Matias Caccia·Adolfo M. García·Sheehan D. Fisher·Martin G. Frasch
View original source ↗Read source document ↗Export metadata ↓

Abstract

Whether voice biomarkers of depression generalize across clinical settings is largely untested. Generalization is usually framed as a question about populations. It is also a question about the outcome instrument a model is scored against -- a dimension largely unexamined. In a US-nationwide online study, 446 sessions from 390 pregnant participants at 22 weeks' gestation (analytical N=316) gave four voice recordings each, the PHQ-8 and a modified 9-item EPDS. Discrimination was assessed under leakage-controlled cross-validation with inside-fold selection, participant-grouped folds, a negative-control harness and multiplicity adjustment across a pre-specified 4 task x 4 outcome grid. The prenatal-trained model was applied to two general-psychiatric corpora (DAIC-WOZ, N=189; E-DAIC, N=219) under pure held-out inference; an open-source model trained on ~35,000 individuals was applied without refitting to all three. The pre-registered within-cohort outcome performed at chance (AUC 0.494, 95% CI 0.431-0.560), and no grid cell survived multiplicity adjustment under either of two modeling paradigms. The prenatal-trained model did not transfer (AUC 0.505, 0.478). Transfer in the reverse direction depended on the instrument, not the population: the general-population model reached 0.706-0.708 on general-psychiatric speech, 0.510 against the PHQ-8 in pregnant women, and 0.645 against the modified EPDS in the same women. The mechanism is visible at item level: the model tracks affective distress and is flat on somatic items, while the PHQ-8 in pregnancy is dominated by somatic content that gestation elevates. Validation should specify population, elicitation task and outcome instrument; a tool validated against one instrument should not be assumed to work against another. This version supersedes v1: a label scoring defect found in peer review is corrected and all analyses redone.

Explore related subjects

q-bio.QM

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Rachel L. Wiley, Jim Schwoebel, Joel Shor, Matias Caccia, Adolfo M. García, Sheehan D. Fisher, Martin G. Frasch. 2025-05-09. Cross-Domain Transfer of Depression Voice Biomarkers Depends on the Outcome Instrument: Leakage-Controlled Cross-Sectional Evaluation Study. https://arxiv.org/abs/2505.06412

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Biology-in-the-loop: Amortized Adaptive Hit Discovery in CRISPR Screens

Many biological discovery problems require experiments to be selected sequentially under constrained budgets. CRISPR screening is a prominent example, as exhaustive perturbation testing is often infeasible and candidate perturbations must instead be prioritized over multiple experimental rounds. Despite the importance of this problem, existing benchmarks for adaptive hit discovery remain limited in scale and diversity. Here, we introduce AssayBench-Loop, a large-scale benchmark for adaptive hit discovery comprising 1,389 CRISPR screens across five phenotype categories. Beyond enabling systematic evaluation, its scale makes it possible to learn acquisition strategies across historical experiments. Building on this resource, we introduce AssayLoop, a sequential experimental design framework combining AssayFormer, a transformer-based amortized acquisition policy trained across historical screens to adapt from experimental feedback, with LLM-derived biological priors through an adaptive handoff. In this view, completed experiments become training data for learning how accumulated evidence should guide what to test next, while LLMs provide prior biological knowledge to seed the search. We further introduce AssayLLM, showing that the same principle can be extended directly to an LLM through task-specific post-training. On temporally held-out screens, AssayLoop achieves a 5.67-fold enrichment over random selection and recovers 27.7% of hits after assaying approximately 5% of the candidate library, outperforming existing adaptive-design methods and standalone LLMs, and AssayFormer alone. Performance improves with increasing historical training data and transfers to phenotype categories excluded from training. These results demonstrate the value of learning acquisition policies across historical experiments and combining them with broad biological priors for efficient adaptive hit discovery.

q-bio.QM↗
arXiv2026

Multi-Task Bacterial Colony Detection and Classification Using YOLOv8 with Edge Optimization for Resource-Constrained Deployment

Manual counting and classification of bacterial colonies are critical yet labor-intensive tasks in microbiology, prone to human error particularly on densely populated plates. This work proposes a multi-task deep learning framework trained on the Annotated Germs for Automated Recognition (AGAR) dataset (18,000 images; 9,202 training / 3,067 testing) to automate Colony Forming Unit (CFU) enumeration and species classification. A custom multi-task CNN employing global regression served as the baseline, but demonstrated limited performance in clustered colony environments due to the absence of spatial localization. To address this, a YOLOv8 object detection architecture was adopted with high-resolution 1024x1024 inputs, enabling instance-level colony detection and label assignment. The model achieved a classification accuracy of 98.13% and a counting accuracy of 98.27% (within a 10-colony margin), demonstrating strong predictive capability. To bridge the gap between model performance and practical deployability, the trained model was optimized through unstructured and structured pruning, ONNX conversion, and reduced-precision inference (FP32, FP16, INT8). On a Raspberry Pi 4B, ONNX FP32 and FP16 variants offered the best balance between inference speed (~6.4s) and accuracy (MAE ~2.20). Unstructured pruning preserved predictive accuracy (MAE ~2.01) without runtime gains, while structured pruning resulted in significant accuracy degradation (MAE ~6.3), revealing the sensitivity of instance-level colony detection to architectural compression. These findings provide practical guidance for selecting optimization strategies in resource-constrained laboratory deployments.

q-bio.QM↗
arXiv2026

ADMET-EvO: a self-evolving scientific agent for sustained research across heterogeneous tasks

Scientific agents can move beyond automated model building by using accumulated evidence to revise both their questions and experimental strategies. The challenge is sustaining this adaptation across heterogeneous tasks without overfitting decisions to internal validation. Absorption, distribution, metabolism, excretion and toxicity (ADMET) prediction provides a demanding setting across diverse assays, datasets and chemical domains. We therefore developed ADMET-EvO, an evidence-gated agent that formalizes endpoints, generates falsifiable hypotheses and tests interventions across data, feature and model axes. It carries supported, rejected and inconclusive outcomes forward to guide each new cycle. Across the 22-task Therapeutics Data Commons (TDC) ADMET benchmark, ADMET-EvO achieved the highest task-normalized score of 96.77. Evidence-guided selection reduced cumulative fitting time by 72.2% within a predefined non-inferiority margin. It also formalized 43 toxicity-related tasks and constructed endpoint-specific predictors. Together, these results show how ADMET-EvO can accumulate evidence, revise its strategy and expand its research scope over time.

q-bio.QM↗