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arXiv · 2506.19736

Dual-energy extraction for proton therapy and imaging: validation on a clinical synchrotron-based facility

Alexander A. Pryanichnikov·Dmitry Shwartz·Jon Feldmand·Joao Seco·Maria Francesca Spadea
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Abstract

The purpose of this study was to investigate the feasibility of extracting proton beams with two distinct energies within a single synchrotron cycle. The energy difference between the beams should be sufficient to use one beam as a range probe to guide the second therapeutic beam in a synchrotron-based proton therapy facility. A clinical synchrotron-based proton therapy facility with a maximum clinical energy of 250 megaeV (MeV) and an experimental energy capability of 330 MeV was used for the study. The synchrotron's internal diagnostic equipment, including beam orbit monitors, dipole magnetic field sensors, acceleration frequency monitors, and energy measurement devices, was used to characterize the properties of the beams within the synchrotron and during extraction. External dosimetric equipment included a PTW water tank fitted with two ionization chambers and an ionization chamber array. These were used to validate dual-energy extraction at the irradiation isocenter independently. Dual-energy extraction was demonstrated across three defined energy ranges: low (75-110 MeV), intermediate (120-155 MeV), and high (195-230 MeV). Both re-acceleration and de-acceleration modes were tested and validated. This preliminary study achieved an energy difference of 35 MeV between extracted beams across the three evaluated energy ranges. This corresponds to clinical targets used under standard operating conditions and does not require hardware modifications. Future studies should explore adjusting the control software to enable target switching during a single cycle or the use of suboptimal targets for higher-energy beams. This would allow for active, real-time range probing. Combining modified dual-energy extraction parameters with low-intensity extraction for high-energy beams shows great promise in enabling simultaneous proton imaging and therapy within a single synchrotron cycle.

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Alexander A. Pryanichnikov, Dmitry Shwartz, Jon Feldmand, Joao Seco, Maria Francesca Spadea. 2025-06-24. Dual-energy extraction for proton therapy and imaging: validation on a clinical synchrotron-based facility. https://arxiv.org/abs/2506.19736

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