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arXiv · 2507.01909

Modality-agnostic, patient-specific digital twins modeling temporally varying digestive motion

Jorge Tapias Gomez·Nishant Nadkarni·Lando S. Bosma·Jue Jiang·Ergys D. Subashi·William P. Segars·James M. Balter·Mert R Sabuncu·Neelam Tyagi·Harini Veeraraghavan
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Abstract

Objective: Clinical implementation of deformable image registration (DIR) requires voxel-based spatial accuracy metrics such as manually identified landmarks, which are challenging to implement for highly mobile gastrointestinal (GI) organs. To address this, patient-specific digital twins (DT) modeling temporally varying motion were created to assess the accuracy of DIR methods. Approach: 21 motion phases simulating digestive GI motion as 4D sequences were generated from static 3D patient scans using published analytical GI motion models through a semi-automated pipeline. Eleven datasets, including six T2w FSE MRI (T2w MRI), two T1w 4D golden-angle stack-of-stars, and three contrast-enhanced CT scans. The motion amplitudes of the DTs were assessed against real patient stomach motion amplitudes extracted from independent 4D MRI datasets. The generated DTs were then used to assess six different DIR methods using target registration error, Dice similarity coefficient, and the 95th percentile Hausdorff distance using summary metrics and voxel-level granular visualizations. Finally, for a subset of T2w MRI scans from patients treated with MR-guided radiation therapy, dose distributions were warped and accumulated to assess dose warping errors, including evaluations of DIR performance in both low- and high-dose regions for patient-specific error estimation. Main results: Our proposed pipeline synthesized DTs modeling realistic GI motion, achieving mean and maximum motion amplitudes and a mean log Jacobian determinant within 0.8 mm and 0.01, respectively, similar to published real-patient gastric motion data. It also enables the extraction of detailed quantitative DIR performance metrics and rigorous validation of dose mapping accuracy. Significance: The pipeline enables rigorously testing DIR tools for dynamic, anatomically complex regions enabling granular spatial and dosimetric accuracies.

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Jorge Tapias Gomez, Nishant Nadkarni, Lando S. Bosma, Jue Jiang, Ergys D. Subashi, William P. Segars, James M. Balter, Mert R Sabuncu, Neelam Tyagi, Harini Veeraraghavan. 2025-07-02. Modality-agnostic, patient-specific digital twins modeling temporally varying digestive motion. https://doi.org/10.1088/1361-6560/ae2b46

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