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arXiv · 2507.09697

Curvature-adaptive gigapixel microscopy at submicron resolution and centimeter scale

Xi Yang·Haitao Chen·Lucas Kreiss·Clare B. Cook·Genevieve Kuczewski·Mark Harfouche·Martin O. Bohlen·Roarke Horstmeyer
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Abstract

Large-area microscopy with submicron resolution is limited by tradeoffs between field of view (FOV), resolution, and imaging speed. Samples are rarely flat across centimeter-scale FOV, which often requires existing solutions to use mechanical scanning to ensure focused capture at reduced throughput. Here, we present PANORAMA, a single-shot, re-imaging microscope that achieves seamless, gigapixel imaging over a 16.3$\times$18.8 $\text{mm}^2$ FOV at 0.84 um resolution without mechanical scanning. By using a telecentric photolithography lens, a large-aperture tube lens, and a flat micro-camera array with adaptive per-camera focus control, PANORAMA maintains submicron focus across flat, curved or uneven samples that span centimeters. This approach improves imaging throughput and adaptability, enabling gigapixel multi-modal microscopy of large flat and non-flat samples in one shot, thus broadening its applications in biomedical and materials imaging.

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Xi Yang, Haitao Chen, Lucas Kreiss, Clare B. Cook, Genevieve Kuczewski, Mark Harfouche, Martin O. Bohlen, Roarke Horstmeyer. 2025-07-13. Curvature-adaptive gigapixel microscopy at submicron resolution and centimeter scale. https://arxiv.org/abs/2507.09697

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