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arXiv · 2507.15631

A powerful procedure that controls the false discovery rate with directional information

Zhaoyang Tian·Kun Liang·Pengfei Li
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Abstract

In many multiple testing applications in genetics, the signs of test statistics provide useful directional information, such as whether genes are potentially up- or down-regulated between two experimental conditions. However, most existing procedures that control the false discovery rate (FDR) are $p$-value based and ignore such directional information. We introduce a novel procedure, the signed-knockoff procedure, to utilize the directional information and control the FDR in finite samples. We demonstrate the power advantage of our procedure through simulation studies and two real applications.

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Zhaoyang Tian, Kun Liang, Pengfei Li. 2025-07-21. A powerful procedure that controls the false discovery rate with directional information. https://doi.org/10.1111/biom.13277

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