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arXiv · 2507.18842

Towards reliable use of artificial intelligence to classify otitis media using otoscopic images: Addressing bias and improving data quality

Yixi Xu·Al-Rahim Habib·Graeme Crossland·Hemi Patel·Chris Perry·Kris Bock·Tony Lian·William B. Weeks·Rahul Dodhia·Juan Lavista Ferres·Narinder Pal Singh
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Abstract

Ear disease contributes significantly to global hearing loss, with recurrent otitis media being a primary preventable cause in children, impacting development. Artificial intelligence (AI) offers promise for early diagnosis via otoscopic image analysis, but dataset biases and inconsistencies limit model generalizability and reliability. This retrospective study systematically evaluated three public otoscopic image datasets (Chile; Ohio, USA; T\"urkiye) using quantitative and qualitative methods. Two counterfactual experiments were performed: (1) obscuring clinically relevant features to assess model reliance on non-clinical artifacts, and (2) evaluating the impact of hue, saturation, and value on diagnostic outcomes. Quantitative analysis revealed significant biases in the Chile and Ohio, USA datasets. Counterfactual Experiment I found high internal performance (AUC > 0.90) but poor external generalization, because of dataset-specific artifacts. The T\"urkiye dataset had fewer biases, with AUC decreasing from 0.86 to 0.65 as masking increased, suggesting higher reliance on clinically meaningful features. Counterfactual Experiment II identified common artifacts in the Chile and Ohio, USA datasets. A logistic regression model trained on clinically irrelevant features from the Chile dataset achieved high internal (AUC = 0.89) and external (Ohio, USA: AUC = 0.87) performance. Qualitative analysis identified redundancy in all the datasets and stylistic biases in the Ohio, USA dataset that correlated with clinical outcomes. In summary, dataset biases significantly compromise reliability and generalizability of AI-based otoscopic diagnostic models. Addressing these biases through standardized imaging protocols, diverse dataset inclusion, and improved labeling methods is crucial for developing robust AI solutions, improving high-quality healthcare access, and enhancing diagnostic accuracy.

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Yixi Xu, Al-Rahim Habib, Graeme Crossland, Hemi Patel, Chris Perry, Kris Bock, Tony Lian, William B. Weeks, Rahul Dodhia, Juan Lavista Ferres, Narinder Pal Singh. 2025-07-24. Towards reliable use of artificial intelligence to classify otitis media using otoscopic images: Addressing bias and improving data quality. https://arxiv.org/abs/2507.18842

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