Emergence of run-and-tumble-like swimming in self-propelling artificial swimmers in soft microchannels

Abstract

Biological microswimmers often encounter deformable boundaries in physiological conditions; for instance, the viscoelastic walls of reproductive tract during migration of spermatozoa, or host tissue during early bacterial biofilm formation. However, the combined influence of elastic and hydrodynamic cues on microswimmer dynamics is poorly understood. Here, we experimentally investigate how the softness of microchannel walls affects the swimming characteristics of self-propelling microswimmers, using autophoretic active droplets as a model system. Remarkably, in a soft microchannel, a self-propelling droplet exhibits a run-and-tumble-like motility characterized by abrupt reorientations in the swimming direction, which are accompanied by local reduction and subsequent increase in the swimming speed. Such emergent swimming dynamics in response to increasing softness of microchannels have been previously unobserved for synthetic microswimmers. Using 3D boundary integral simulations and fluorescence microscopy experiments, we show that the coupling between the elastohydrodynamic interactions and the chemo-hydrodynamics, inherent in the self-propulsion mechanism, in a soft narrow confinement results in alterations in the swimming characteristics. We envisage that such adaptation of autophoretic microswimmers to changes in the softness of microchannel walls will pave the way for novel methods for tuning active agents in complex environment solely by exploiting the elasticity of confining walls.