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arXiv · 2508.15776

Implementing Zero Trust Architecture to Enhance Security and Resilience in the Pharmaceutical Supply Chain

Saeid Ghasemshirazi·Ghazaleh Shirvani·Marziye Ranjbar Tavakoli·Bahar Ghaedi·Mohammad Amin Langarizadeh
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Abstract

The pharmaceutical supply chain faces escalating cybersecurity challenges threatening patient safety and operational continuity. This paper examines the transformative potential of zero trust architecture for enhancing security and resilience within this critical ecosystem. We explore the challenges posed by data breaches, counterfeiting, and disruptions and introduce the principles of continuous verification, least-privilege access, and data-centric security inherent in zero trust. Real-world case studies illustrate successful implementations. Benefits include heightened security, data protection, and adaptable resilience. As recognized by researchers and industrialists, a reliable drug tracing system is crucial for ensuring drug safety throughout the pharmaceutical production process. One of the most pivotal domains within the pharmaceutical industry and its associated supply chains where zero trust can be effectively implemented is in the management of narcotics, high-health-risk drugs, and abusable substances. By embracing zero trust, the pharmaceutical industry fortifies its supply chain against constantly changing cyber threats, ensuring the trustworthiness of critical medical operations.

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Saeid Ghasemshirazi, Ghazaleh Shirvani, Marziye Ranjbar Tavakoli, Bahar Ghaedi, Mohammad Amin Langarizadeh. 2025-07-31. Implementing Zero Trust Architecture to Enhance Security and Resilience in the Pharmaceutical Supply Chain. https://arxiv.org/abs/2508.15776

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