Tree-based methods for length-biased survival data

Abstract

Left-truncated survival data commonly arise in prevalent cohort studies, where only individuals who have experienced disease onset and survived until enrollment in the study. When the onset process follows a stationary Poisson process, the resulting data are length-biased. This sampling mechanism induces a selection bias towards longer survival individuals, and statistical methods for traditional survival data are not directly applicable. While tree-based methods developed for left-truncated data can be applied, they may be inefficient for length-biased data, as they do not account for the distribution of truncation times. To address this, we propose new survival trees and forests for length-biased right-censored data within the conditional inference framework. Our approach uses a score function derived from the full likelihood to construct permutation test statistics for variable splitting. For survival prediction, we consider two estimators of the unbiased survival function, differing in statistical efficiency and computational complexity. These elements enhance efficiency in tree construction and improve accuracy of survival prediction in ensemble settings. Simulation studies demonstrate efficiency gains in both tree recovery and survival prediction, often exceeding the gains from ensembling alone. We further illustrate the utility of the proposed methods using lung cancer data from the Cancer Public Library Database, a nationwide cancer registry in South Korea.