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arXiv · 2509.09533

Bioluminescence tomography via a shape optimization method based on a complex-valued model

Qianqian Wu·Rongfang Gong·Wei Gong·Ziyi Zhang·Shengfeng Zhu
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Abstract

In this study, we investigate the inverse source problem arising in bioluminescence tomography, the objective of which is to reconstruct both the support and the intensity of an internal light source from boundary measurements governed by an elliptic model. A shape optimization framework is developed in which the source intensity and its support are decoupled through first-order optimality conditions. To enhance the stability of the reconstruction, we incorporate a parameter-dependent coupled complex boundary method together with perimeter and volume regularizations. Source support is represented by a level set function, allowing the algorithm to naturally accommodate topological changes and recover multiple, closely spaced, or nested source regions. Theoretical justifications for the proposed formulation and regularization strategy are established, and extensive numerical experiments are performed to assess the reconstruction accuracy for both noise-free and noisy data. The results demonstrate that our method achieves robust and accurate recovery of source geometry and intensity, and exhibits clear advantages over existing approaches.

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Qianqian Wu, Rongfang Gong, Wei Gong, Ziyi Zhang, Shengfeng Zhu. 2025-09-11. Bioluminescence tomography via a shape optimization method based on a complex-valued model. https://arxiv.org/abs/2509.09533

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