Future of Brain Health: From Developmental Insights to Clinical Translation

Mariela Chertoff; Martin G Frasch; Eduardo T Cánepa; Gerlinde A. S. Metz; Marta Cristina Antonelli; Sheehan D. Fisher; Bea R. H. Van den Bergh

arXiv · 2509.21332

Future of Brain Health: From Developmental Insights to Clinical Translation

Mariela Chertoff·Martin G Frasch·Eduardo T Cánepa·Gerlinde A. S. Metz·Marta Cristina Antonelli·Sheehan D. Fisher·Bea R. H. Van den Bergh

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Abstract

This review highlights brain health as a dynamic process shaped by both genetic and environmental influences throughout development. Critical periods provide unique windows of heightened neural plasticity, during which genetic-environmental interactions and parental influences profoundly impact brain maturation. Frameworks such as DOHaD, ACEs, and neurosocial plasticity elucidate how early-life experiences modulate long-term cognitive and emotional outcomes. Brain health science is emerging as a field integrating neuroscience, public health, and social context. Resilience-oriented approaches and predictive processing, offer renewed perspectives on adaptive brain function. Clinically, understanding critical periods and plasticity spanning from fetal life to old age, has implications for early detection, targeted interventions, and resilience-oriented strategies, emphasizing the potential for lifelong optimization of mental health.

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Mariela Chertoff, Martin G Frasch, Eduardo T Cánepa, Gerlinde A. S. Metz, Marta Cristina Antonelli, Sheehan D. Fisher, Bea R. H. Van den Bergh. 2025-09-08. Future of Brain Health: From Developmental Insights to Clinical Translation. https://arxiv.org/abs/2509.21332

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