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arXiv · 2510.04084

Bridging integrated information theory and the free-energy principle in living neuronal networks

Teruki Mayama·Dai Akita·Sota Shimizu·Yuki Takano·Hirokazu Takahashi
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Abstract

Integrated Information Theory (IIT) links consciousness to integrated causal structure, whereas the Free-Energy Principle (FEP) explains self-organization through variational free-energy minimization. Their relationship in living neural systems remains unclear. We analyzed dissociated neuronal cultures learning to infer hidden signal sources. Across repeated stimulation, variational free energy decreased, while inference accuracy and Bayesian surprise, defined as the divergence between prior and posterior beliefs, increased. An IIT-inspired integrated-information proxy and main-complex size followed a non-monotonic, hill-shaped trajectory. The proxy correlated most strongly with Bayesian surprise and more weakly with accuracy and variational free energy. An Ising-model analysis indicated that Bayesian surprise and integrated information can be jointly amplified near shared positive critical modes and suggested how early connectivity development followed by response stabilization could generate the observed trajectory. These results link belief updating to integrated information in living neuronal networks and provide an empirical point of contact between IIT and the FEP.

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Teruki Mayama, Dai Akita, Sota Shimizu, Yuki Takano, Hirokazu Takahashi. 2025-10-05. Bridging integrated information theory and the free-energy principle in living neuronal networks. https://arxiv.org/abs/2510.04084

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