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arXiv · 2510.14994

Control of Neuronal Survival and Development Using Conductive Diamond

Samira Falahatdoost·Yair D. J. Prawer·Danli Peng·Andre Chambers·Hualin Zhan·Leon Pope·Alastair Stacey·Arman Ahnood·Hassan N. Al Hashem·Sorel E. De Leon·David J. Garrett·Kate Fox·Michael B. Clark·Michael R. Ibbotson·Steven Prawer·Wei Tong
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Abstract

This study demonstrates the control of neuronal survival and development using nitrogen-doped ultrananocrystalline diamond (N-UNCD). We highlight the role of N-UNCD in regulating neuronal activity via near-infrared illumination, demonstrating the generation of stable photocurrents that enhance neuronal survival and neurite outgrowth and foster a more active, synchronized neuronal network. Whole transcriptome RNA sequencing reveals that diamond substrates improve cellular-substrate interaction by upregulating extracellular matrix and gap junction-related genes. Our findings underscore the potential of conductive diamond as a robust and biocompatible platform for noninvasive and effective neural tissue engineering.

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Samira Falahatdoost, Yair D. J. Prawer, Danli Peng, Andre Chambers, Hualin Zhan, Leon Pope, Alastair Stacey, Arman Ahnood, Hassan N. Al Hashem, Sorel E. De Leon, David J. Garrett, Kate Fox, Michael B. Clark, Michael R. Ibbotson, Steven Prawer, Wei Tong. 2025-10-09. Control of Neuronal Survival and Development Using Conductive Diamond. https://doi.org/10.1021/acsami.3c14680

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