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arXiv · 2510.24115

HistoLens: An Interactive XAI Toolkit for Verifying and Mitigating Flaws in Vision-Language Models for Histopathology

Sandeep Vissapragada·Vikrant Sahu·Gagan Raj Gupta·Vandita Singh
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Abstract

For doctors to truly trust artificial intelligence, it can't be a black box. They need to understand its reasoning, almost as if they were consulting a colleague. We created HistoLens1 to be that transparent, collaborative partner. It allows a pathologist to simply ask a question in plain English about a tissue slide--just as they would ask a trainee. Our system intelligently translates this question into a precise query for its AI engine, which then provides a clear, structured report. But it doesn't stop there. If a doctor ever asks, "Why?", HistoLens can instantly provide a 'visual proof' for any finding--a heatmap that points to the exact cells and regions the AI used for its analysis. We've also ensured the AI focuses only on the patient's tissue, just like a trained pathologist would, by teaching it to ignore distracting background noise. The result is a workflow where the pathologist remains the expert in charge, using a trustworthy AI assistant to verify their insights and make faster, more confident diagnoses.

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Sandeep Vissapragada, Vikrant Sahu, Gagan Raj Gupta, Vandita Singh. 2025-10-28. HistoLens: An Interactive XAI Toolkit for Verifying and Mitigating Flaws in Vision-Language Models for Histopathology. https://arxiv.org/abs/2510.24115

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