arXiv · 2511.00231
Towards 1000-fold Electron Microscopy Image Compression for Connectomics via VQ-VAE with Transformer Prior
Abstract
Petascale electron microscopy (EM) datasets push storage, transfer, and downstream analysis toward their current limits. We present a vector-quantized variational autoencoder-based (VQ-VAE) compression framework for EM that spans 16x to 1024x and enables pay-as-you-decode usage: top-only decoding for extreme compression, with an optional Transformer prior that predicts bottom tokens (without changing the compression ratio) to restore texture via feature-wise linear modulation (FiLM) and concatenation; we further introduce an ROI-driven workflow that performs selective high-resolution reconstruction from 1024x-compressed latents only where needed.
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Fuming Yang, Yicong Li, Hanspeter Pfister, Jeff W. Lichtman, Yaron Meirovitch. 2025-10-31. Towards 1000-fold Electron Microscopy Image Compression for Connectomics via VQ-VAE with Transformer Prior. https://arxiv.org/abs/2511.00231
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