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arXiv · 2512.08257

Geometric-Stochastic Multimodal Deep Learning for Predictive Modeling of SUDEP and Stroke Vulnerability

Preksha Girish·Rachana Mysore·Mahanthesha U·Shrey Kumar·Misbah Fatimah Annigeri·Tanish Jain
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Abstract

Sudden Unexpected Death in Epilepsy (SUDEP) and acute ischemic stroke are life-threatening conditions involving complex interactions across cortical, brainstem, and autonomic systems. We present a unified geometric-stochastic multimodal deep learning framework that integrates EEG, ECG, respiration, SpO2, EMG, and fMRI signals to model SUDEP and stroke vulnerability. The approach combines Riemannian manifold embeddings, Lie-group invariant feature representations, fractional stochastic dynamics, Hamiltonian energy-flow modeling, and cross-modal attention mechanisms. Stroke propagation is modeled using fractional epidemic diffusion over structural brain graphs. Experiments on the MULTI-CLARID dataset demonstrate improved predictive accuracy and interpretable biomarkers derived from manifold curvature, fractional memory indices, attention entropy, and diffusion centrality. The proposed framework provides a mathematically principled foundation for early detection, risk stratification, and interpretable multimodal modeling in neural-autonomic disorders.

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Preksha Girish, Rachana Mysore, Mahanthesha U, Shrey Kumar, Misbah Fatimah Annigeri, Tanish Jain. 2025-12-09. Geometric-Stochastic Multimodal Deep Learning for Predictive Modeling of SUDEP and Stroke Vulnerability. https://arxiv.org/abs/2512.08257

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