Constraint-Free Coherent Diffraction Imaging via Physics-Guided Neural Fields

Abstract

CDI is a lensless imaging technique that enables atomic-resolution imaging of non-crystalline specimens and their dynamics. However, its broader implementation has been hindered by the instability and ill-posedness of its reconstruction process, known as phase retrieval, which relies heavily on handcrafted, object-specific constraints. To overcome the key limitations, we propose CDIP, a robust phase-retrieval framework that eliminates the need for such constraints by combining untrained coordinate-based neural fields for static and dynamic reconstructions and a physics-consistent forward model. We evaluate CDIP on simulated and experimental datasets that involve both static samples and dynamic processes, demonstrating that it substantially outperforms classical iterative algorithms and deep-learning baselines in terms of fidelity and stability. These results highlight a paradigm shift in both static and time-resolved CDI reconstruction, providing a broadly applicable framework for coherent imaging modalities such as ptychography and holography, across X-ray, electron, and optical probes.