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arXiv · 2512.16188

A Multi-scale Fused Graph Neural Network with Inter-view Contrastive Learning for Spatial Transcriptomics Data Clustering

Jianping Mei·Siqi Ai·Ye Yuan
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Abstract

Spatial transcriptomics enables genome-wide expression analysis within native tissue context, yet identifying spatial domains remains challenging due to complex gene-spatial interactions. Existing methods typically process spatial and feature views separately, fusing only at output level - an "encode-separately, fuse-late" paradigm that limits multi-scale semantic capture and cross-view interaction. Accordingly, stMFG is proposed, a multi-scale interactive fusion graph network that introduces layer-wise cross-view attention to dynamically integrate spatial and gene features after each convolution. The model combines cross-view contrastive learning with spatial constraints to enhance discriminability while maintaining spatial continuity. On DLPFC and breast cancer datasets, stMFG outperforms state-of-the-art methods, achieving up to 14% ARI improvement on certain slices.

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Jianping Mei, Siqi Ai, Ye Yuan. 2025-12-18. A Multi-scale Fused Graph Neural Network with Inter-view Contrastive Learning for Spatial Transcriptomics Data Clustering. https://arxiv.org/abs/2512.16188

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