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arXiv · 2601.16904

Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution

L. Duraffourg·H. Borges·M. Fernandes·M. Beurrier-Bousquet·J. Baraillon·B. Taurel·J. Le Galudec·K. Vianey·C. Maisin·L. Samaison·F. Staroz·M. Dupoy
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Abstract

We present a rapid, large-field bimodal imaging platform that integrates conventional brightfield microscopy with a lensless IR imaging scanner, enabling whole-slide IR image stack acquisition in minutes. Using a dedicated deep learning model, we implement an optical HE staining strategy based on subcellular morpho-spectral fingerprinting.

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L. Duraffourg, H. Borges, M. Fernandes, M. Beurrier-Bousquet, J. Baraillon, B. Taurel, J. Le Galudec, K. Vianey, C. Maisin, L. Samaison, F. Staroz, M. Dupoy. 2026-01-23. Clinical Feasibility of Label-Free Digital Staining Using Mid-Infrared Microscopy at Subcellular Resolution. https://arxiv.org/abs/2601.16904

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