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arXiv · 2602.08576

Percolation and Threshold-like Behavior in Multiple Sclerosis Progression

Nikola Mirkov·Dušan S. Radivojević·Slobodan Maletić
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Abstract

In this study we investigate the Percolation Hypothesis for Multiple Sclerosis Progression. The methodology relies on cross-reference analysis centered around a question: What is the evidence for a Percolation/phase-transition hypothesis in Multiple Sclerosis (MS), especially the idea that the RRMS dynamic balance can abruptly break akin to crossing a percolation threshold into SPMS? We identify theoretical models invoking percolation/critical thresholds, network/connectome studies assessing percolation robustness or threshold-like behavior, clinical markers showing thresholds or early-warning signals, and counter-evidence arguing for gradual/continuum transitions.

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Nikola Mirkov, Dušan S. Radivojević, Slobodan Maletić. 2026-02-09. Percolation and Threshold-like Behavior in Multiple Sclerosis Progression. https://arxiv.org/abs/2602.08576

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