End-user validation of BRIGHT with custom-developed graphical user interface applied to cervical cancer brachytherapy

Leah R. M. Dickhoff; Ellen M. Kerkhof; Heloisa H. Deuzeman; Laura A. Velema; Stephanie M. de Boer; Lavinia A. L. Verhagen; Danique L. J. Barten; Bradley R. Pieters; Lukas J. A. Stalpers; Renzo J. Scholman; Pedro M. Matos; Anton Bouter; Carien L. Creutzberg; Peter A. N. Bosman; Tanja Alderliesten

arXiv · 2602.16321

End-user validation of BRIGHT with custom-developed graphical user interface applied to cervical cancer brachytherapy

Leah R. M. Dickhoff·Ellen M. Kerkhof·Heloisa H. Deuzeman·Laura A. Velema·Stephanie M. de Boer·Lavinia A. L. Verhagen·Danique L. J. Barten·Bradley R. Pieters·Lukas J. A. Stalpers·Renzo J. Scholman·Pedro M. Matos·Anton Bouter·Carien L. Creutzberg·Peter A. N. Bosman·Tanja Alderliesten

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Abstract

Multi-objective optimisation using BRIGHT has proven insightful and effective in prostate cancer brachytherapy treatment planning. BRachytherapy via artificially Intelligent GOMEA-Heuristic based Treatment planning (BRIGHT) generates multiple treatment plans, each with a different trade-off between tumour coverage and organs-at-risk sparing. BRIGHT was recently extended to cervical cancer brachytherapy. In this study, we present a novel, custom-developed graphical user interface (GUI) that enables plan navigation, pairwise comparisons, dose distribution visualisation, and possibility for adjustments - essential for efficient clinical use of BRIGHT. End-user validation of BRIGHT with the dedicated GUI was conducted for cervical cancer brachytherapy by emulating clinical practice in ten previously treated patients. A multidisciplinary brachytherapy team used BRIGHT to create new treatment plans. GUI usability was assessed using the System Usability Scale (SUS). BRIGHT plan quality was compared to clinical practice via blinded one-on-one comparisons. The GUI offered helpful features for plan navigation and evaluation, giving users quick insight into whether planning aims are achievable and what treatment options are available. The overall SUS score was 83.3, indicating an 'excellent' system. BRIGHT outperformed clinical practice in five out of ten patients regarding the coverage-sparing trade-off and performed equally well in the remaining five. The BRIGHT plan was preferred over the clinical plan in eight out of ten patients, four of which showed clinically relevant differences. The clinical plan was preferred in two patients, neither with clinically relevant differences. In conclusion, BRIGHT, with its dedicated GUI, is a clinically viable and user-friendly tool for treatment planning in cervical cancer brachytherapy.

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Leah R. M. Dickhoff, Ellen M. Kerkhof, Heloisa H. Deuzeman, Laura A. Velema, Stephanie M. de Boer, Lavinia A. L. Verhagen, Danique L. J. Barten, Bradley R. Pieters, Lukas J. A. Stalpers, Renzo J. Scholman, Pedro M. Matos, Anton Bouter, Carien L. Creutzberg, Peter A. N. Bosman, Tanja Alderliesten. 2026-02-18. End-user validation of BRIGHT with custom-developed graphical user interface applied to cervical cancer brachytherapy. https://arxiv.org/abs/2602.16321

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