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arXiv · 2603.00882

Solving a Nonlinear Blind Inverse Problem for Tagged MRI with Physics and Deep Generative Priors

Zhangxing Bian·Shuwen Wei·Samuel W. Remedios·Junyu Chen·Aaron Carass·Blake E. Dewey·Jerry L. Prince
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Abstract

Tagged MRI enables tracking internal tissue motion non-invasively. It encodes motion by modulating anatomy with periodic tags, which deform along with tissue. However, the entanglement between anatomy, tags and motion poses significant challenges for post-processing. The existence of tags and imaging blur hinders downstream tasks such as segmenting anatomy. Tag fading, due to T1-relaxation, disrupts the brightness constancy assumption for motion tracking. For decades, these challenges have been handled in isolation and sub-optimally. In contrast, we introduce a blind and nonlinear inverse framework for tagged MRI that, for the first time, unifies these tasks: anatomical image recovery, high-resolution cine image synthesis, and motion estimation. At its core, the synergy of MR physics and generative priors enables us to blindly estimate the unknown forward imaging models and high-resolution underlying anatomy, while simultaneously tracking 3D diffeomorphic Lagrangian motion over time. Experiments on tagged brain MRI demonstrate that our approach yields high-resolution anatomy images, cine images, and more accurate motion than specialized methods.

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Zhangxing Bian, Shuwen Wei, Samuel W. Remedios, Junyu Chen, Aaron Carass, Blake E. Dewey, Jerry L. Prince. 2026-03-01. Solving a Nonlinear Blind Inverse Problem for Tagged MRI with Physics and Deep Generative Priors. https://arxiv.org/abs/2603.00882

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