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arXiv · 2603.12341

Self-Reported Side Effects of Semaglutide and Tirzepatide in Online Communities

Neil K. R. Sehgal·Jena Shaw Tronieri·Lyle Ungar·Sharath Chandra Guntuku
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Abstract

Social media can reveal patient experiences with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) that extend beyond clinical trial data. We analyzed 410,198 Reddit posts (May 2019-June 2025) mentioning semaglutide or tirzepatide. A total of 67,008 users self-reported using these medications, and 43.5% described at least one side effect. Gastrointestinal symptoms predominated, including nausea (36.9%), fatigue (16.7%), vomiting (16.3%), constipation (15.3%), and diarrhea (12.6%). Notably, reproductive symptoms (e.g., menstrual irregularities) and temperature-related complaints (e.g., chills, hot flashes) emerged as unrecognized potential effects. These findings highlight patient concerns not well captured in current labeling or trials. Large-scale social media analysis can complement traditional pharmacovigilance by detecting emerging safety signals and expanding understanding of the real-world safety profile of GLP-1 RAs.

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Neil K. R. Sehgal, Jena Shaw Tronieri, Lyle Ungar, Sharath Chandra Guntuku. 2026-03-12. Self-Reported Side Effects of Semaglutide and Tirzepatide in Online Communities. https://arxiv.org/abs/2603.12341

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