ARES OS 2.0: An Orchestration Software Suite for Autonomous Experimentation Systems and Self-Driving Labs

Arthur W. N. Sloan; Robert W. Waelder; Morgen L. Smith; Nicholas Kleiner; Arnas Babeckis; Jason Wheeler; Daylond Hooper; Benji Maruyama

arXiv · 2604.03440

ARES OS 2.0: An Orchestration Software Suite for Autonomous Experimentation Systems and Self-Driving Labs

Arthur W. N. Sloan·Robert W. Waelder·Morgen L. Smith·Nicholas Kleiner·Arnas Babeckis·Jason Wheeler·Daylond Hooper·Benji Maruyama

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Abstract

ARES OS 2.0 (hereinafter ARES OS) is an open-source software suite to enable laboratory automation and closed-loop autonomous experimentation. Its function is to orchestrate experimental actions and data handoff between lab equipment, analysis routines, and experimental planning modules through a service-oriented architecture. ARES OS is abstracted to apply to general experimental flows common in materials science, chemistry, and biology and related disciplines. The core of ARES OS provides central control over all modules, along with the heavy lifting of UI creation, data management, and experimental design tools. ARES OS modules communicate with the core software over protobuf and gRPC, allowing them to be language-agnostic and user-creatable. This allows users to easily implement modules that control experimental hardware, process collected data , or plan experiments to meet their specific research needs. ARES OS lowers the barrier to entry for researchers to build their own self-driving labs, allowing them to focus on scientific programming for their use case and reducing the effort and time needed to bring an autonomous experimentation system online.

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Arthur W. N. Sloan, Robert W. Waelder, Morgen L. Smith, Nicholas Kleiner, Arnas Babeckis, Jason Wheeler, Daylond Hooper, Benji Maruyama. 2026-04-03. ARES OS 2.0: An Orchestration Software Suite for Autonomous Experimentation Systems and Self-Driving Labs. https://arxiv.org/abs/2604.03440

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