Mathematical modeling and analysis of the Notch-Delta pathway

Angela Stevens; Nicola Vassena

Home/Archive/arXiv

arXiv · 2604.05888

Mathematical modeling and analysis of the Notch-Delta pathway

Angela Stevens·Nicola Vassena

View original source ↗Read source document ↗Export metadata ↓

Abstract

In this paper mathematical models for the evolutionary conserved Notch-Delta pathway are developed and analyzed in order to better understand how two neighboring biological cells can become different. We pursue a structure-based stoichiometric type of approach, such that no specific reaction kinetics have to be defined. Only their dependencies on the relevant species participating in the model network are taken into account. Reaction networks and their related systems of ODEs are presented and analyzed with respect to their capacity for symmetry-induced bifurcations. The possibility to obtain a singular Jacobian is analyzed symbolically. This approach is valid for parameter-rich kinetics, where the parametrization of the steady-state fluxes and of the first derivatives of the reaction rates evaluated at the steady state are independent. In this context, also with the help of abstract minimal models, we could mathematically identify some of the Notch pathway's features being more relevant than others.

Explore related subjects

math.DS

Keep this discovery

BibTeX RIS

Angela Stevens, Nicola Vassena. 2026-04-07. Mathematical modeling and analysis of the Notch-Delta pathway. https://arxiv.org/abs/2604.05888

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

arXiv2026

Admissible Fourier Lengths, KAM Reducibility, and Spectral Applications

We develop a perturbative KAM reducibility theory for one-frequency $\mathrm{SL}(2,\mathbb{R})$ cocycles based on an admissible Fourier length $\ell$. The regularity relevant to the iteration is measured by positive adapted Fourier width rather than ordinary smoothness in the Euclidean length $|n|$. The same length governs Fourier decay, truncation and resonance scales, and the arithmetic condition controlling the small divisors. This framework contains the classical analytic and Gevrey settings, while non-monotone choices of $\ell$ allow classical nowhere differentiable Weierstrass-type perturbations and continuous perturbations outside every positive H\"older class. As spectral applications, we obtain purely absolutely continuous spectrum for every phase and $1/2$-H\"older continuity of the integrated density of states for the associated quasiperiodic Schr\"odinger operators. The Aubry dual has pure point spectrum for Lebesgue almost every dual phase, with eigenfunctions exponentially localized in the metric induced by $\ell$. We also construct nowhere differentiable quasiperiodic potentials with purely absolutely continuous Cantor spectrum.

math.DS↗

arXiv2026

Dynamics inside the attracting basins of some skew products

Polynomial skew products in $\mathbb{C}^2$ are maps of the form $F(z,w)=(P(z),Q(z,w))$, where $P$ and $Q$ are polynomials. Their local dynamics have been widely investigated. In this paper, we study the global dynamics inside Fatou components of some skew products. We consider all the inverse images in a Fatou component of a given point and use the Kobayashi metric to measure the distance between points. In the cases we consider, there are always arbitrarily large Kobayashi balls in the complement of these inverse sets.

math.DS↗

arXiv2026

Ergodicity of dynamical systems without uniqueness of orbits

Recently, there has been considerable interest in the study of non-deterministic dynamical systems. To analyze the chaotic behavior of such systems from a measure-theoretic viewpoint, it is desirable to consider ergodicity. However, the classical definition of ergodicity involves invariant sets, whose definition is not unique for non-deterministic dynamical systems. Thus, we are led to the question of which invariance yields an interesting definition of ergodicity. Here, we propose a definition based on the strong backward invariance and show that analogs of classical results hold. We also consider implications of the Birkhoff ergodic theorem for systems without uniqueness of orbits.

math.DS↗