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arXiv · 2604.17291

Poisson Flow Model of Cortical Folding Pattern

Moo K. Chung·Luigi Maccotta·Aaron Struck
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Abstract

Cortical folding reflects coordinated neurodevelopmental processes and provides a sensitive marker of neurological disease. In juvenile myoclonic epilepsy (JME), structural abnormalities are subtle and spatially distributed, limiting the sensitivity of conventional morphometric measures such as cortical thickness. We introduce a Poisson flow model derived from gradients of the mean curvature field on the cortical surface. The method yields a smooth scalar field obtained from a Poisson equation, whose surface gradient defines a flow representation of folding organization. This representation enables spatially coherent characterization of sulcal--gyral patterns and provides a principled geometric framework for studying distributed cortical alterations in JME.

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Moo K. Chung, Luigi Maccotta, Aaron Struck. 2026-04-19. Poisson Flow Model of Cortical Folding Pattern. https://arxiv.org/abs/2604.17291

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