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arXiv · 2604.20739

High-Fidelity Single-Shot Quantitative Differential Phase Microscopy Using Pseudothermal Sagnac Interferometer

Pawel Goclowski·Hong Mao·Maciek Trusiak·Balpreet S. Ahluwalia·Azeem Ahmad
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Abstract

In this letter, a high-fidelity single-shot differential quantitative phase microscopy (dQPM) method is presented to effectively image nearly transparent biological samples. The proposed method is based on a common-path Sagnac interferometric configuration, which provides superior temporal phase stability and robustness against environmental disturbances. The proposed system exploits a pseudothermal source to achieve high spatial sensitivity and generate dense interference fringes for effective single-shot differential quantitative phase imaging. The effectiveness of the proposed system is experimentally demonstrated with various samples, including polystyrene microspheres, a USAF phase target, fixed and live HeLa cells, and mouse kidney tissue.

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Pawel Goclowski, Hong Mao, Maciek Trusiak, Balpreet S. Ahluwalia, Azeem Ahmad. 2026-04-22. High-Fidelity Single-Shot Quantitative Differential Phase Microscopy Using Pseudothermal Sagnac Interferometer. https://arxiv.org/abs/2604.20739

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