Effective strains enable rapid wound closure in jellyfish after injury

Abstract

The jellyfish Clytia hemisphaerica possesses astounding regenerative capacities and is able to close even large wounds within a few hours. This rapid pace of wound closure raises the question whether tissue mechanics, rather than tissue restructuring or cell proliferation, might be underlying the process. We tested this possibility by asking if simple pre-strains within the jellyfish umbrella would be capable of initiating wound closure in a jellyfish body geometry. To this end, we employed an in silico spring lattice model, a coarse-grained model of elastic materials which has previously been established to study tissue mechanics problems. We found that, using radially contractile (but not radially extensile) strains, wound closure can indeed be initiated across a wide range of conditions. This is even true for large cut sizes and, hence, small pieces of remaining tissue material, in good agreement with the experimental findings. Finally, we derived an analytical expression for the expected amount of achievable closure as a function of the residual material angle. These results establish important foundations for further investigations of the biophysics underpinning jellyfish regeneration.