Rheotaxis of microswimmers in colloid-laden channel flow

Abstract

Microswimmers are often found in heterogeneous and crowded environments within narrow conduits under external flow conditions, enabling them to perform interesting translational and rotational maneuvers, such as swimming in the upstream direction, following walls, and oscillatory motion. Studying such systems helps us understand the motility behaviors of microswimmers (pushers, pullers, or neutrals) and develop applications such as targeted drug delivery. To study the motion of microswimmers in a channel flow with the presence of hard, monodisperse spherical colloids, we adopted the spherical squirmer model to represent the microswimmers, along with a mesoscale simulation framework, multi-particle collision dynamics (MPCD), to represent the background fluid. In the absence of colloids, a squirmer in a microchannel flow develops an increased probability of moving away from the walls and oscillates between the walls as the flow speed increases compared to the squirmer speed, with a dominant upstream orientation near the walls. However, the presence of the colloids makes the pusher swim towards the center of the channel and upstream direction, and the puller swim away from the center of the channel at low flow speeds. At high flow speeds, the flow carries all the squirmers, resulting in a dominant upstream direction in the channel center. We observe that this leads to a decrease in the local velocity of the squirmer in the flow direction for pusher, neutral, and puller-type squirmers. We also observe that, for a constant colloidal packing fraction, the local velocity magnitude of the puller along the flow direction is less than that of the pusher.