AutoSci: A Memory-Centric Agentic System for the Full Scientific Research Lifecycle

Weitong Qian; Beicheng Xu; Zhongao Xie; Bowen Fan; Guozheng Tang; Jiale Chen; Xinzhe Wu; Mingtian Yang; Chenyang Di; Jiajun Li; Lingching Tung; Peichao Lai; Yifei Xia; Ziyi Guo; Yanwei Xu; Yanzhao Qin; Shaoduo Gan; Xupeng Miao; Bin Cui

arXiv · 2605.31468

AutoSci: A Memory-Centric Agentic System for the Full Scientific Research Lifecycle

Weitong Qian·Beicheng Xu·Zhongao Xie·Bowen Fan·Guozheng Tang·Jiale Chen·Xinzhe Wu·Mingtian Yang·Chenyang Di·Jiajun Li·Lingching Tung·Peichao Lai·Yifei Xia·Ziyi Guo·Yanwei Xu·Yanzhao Qin·Shaoduo Gan·Xupeng Miao·Bin Cui

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Abstract

Scientific research has traditionally been human-intensive, requiring researchers to coordinate literature, ideas, experiments, manuscripts, and review responses across long project cycles. The rise of LLM-based scientific agents creates an opportunity to automate this process. Such a system must support the full research lifecycle, maintain structured persistent memory across projects, and improve its own research procedures over time. However, existing systems either partially satisfy or fail to satisfy these requirements, leaving a gap for a unified automated scientific research system. As a result, we present AutoSci, a memory-centric agentic system for the full scientific research lifecycle. AutoSci is organized around four modules. SciMem provides schema-governed research memory, separating Long-Term Knowledge Memory for reusable scientific knowledge from Active Research Memory for project-level artifacts such as ideas, experiments, manuscripts, and reviews. SciFlow executes a five-stage lifecycle from literature understanding to rebuttal through a harness that controls state, context, verification, feedback, and orchestration. SciDAG augments difficult skills with DAG-shaped multi-agent operators and reusable stage-specific templates. SciEvolve converts feedback signals from users, experiments, reviews, and external environments into versioned updates to SciMem organization, SciFlow skills, and SciDAG templates. Together, these modules make AutoSci a persistent research environment that can execute, remember, and evolve across research projects. The code repository is available at https://github.com/skyllwt/AutoSci.

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Weitong Qian, Beicheng Xu, Zhongao Xie, Bowen Fan, Guozheng Tang, Jiale Chen, Xinzhe Wu, Mingtian Yang, Chenyang Di, Jiajun Li, Lingching Tung, Peichao Lai, Yifei Xia, Ziyi Guo, Yanwei Xu, Yanzhao Qin, Shaoduo Gan, Xupeng Miao, Bin Cui. 2026-05-29. AutoSci: A Memory-Centric Agentic System for the Full Scientific Research Lifecycle. https://arxiv.org/abs/2605.31468

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