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arXiv · 2606.00767

The Effect of Choice of Metric and Scan Length on Reliability in Resting-State fMRI

Yu Huang·Philip T. Reiss·Seonjoo Lee·R. Todd Ogden
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Abstract

Resting-state fMRI (rs-fMRI) is widely used to investigate brain functional connectivity, but the reliability of these measurements remains a key concern for ensuring reproducibility. The distance-based intraclass correlation coefficient (dbICC) generalizes classical ICC to more general data types, making it well-suited for assessing the reliability of measures of functional connectivity. In this study, we applied dbICC to assess the reliability of rs-fMRI data from the Midnight Scanning Club (MSC) dataset, which consists of 10 subjects, each undergoing 10 sessions of 30-minute rs-fMRI scans. The functional connectivity was estimated using Pearson's correlation coefficients between all pairs of brain regions, resulting in a correlation matrix for each session. We compared two distance metrics-the widely used Frobenius metric and the Affine Invariant Riemannian Metric (AIRM) selected to respect the geometry of the space of covariance matrices-to evaluate how the choice of metric affects the reliability of estimating correlation. In addition, we investigated the impact of scan length and time interval between sessions on reliability. Results based on each metric agreed in some respects but disagreed in others, illustrating the impact of choice of metric. We also found that longer scan lengths significantly improve reliability, while the time interval between sessions has less impact.

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Yu Huang, Philip T. Reiss, Seonjoo Lee, R. Todd Ogden. 2026-05-30. The Effect of Choice of Metric and Scan Length on Reliability in Resting-State fMRI. https://arxiv.org/abs/2606.00767

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