Deterministic access to global viral sequence data enables robust agentic scientific discovery

Ferdous Nasri; Sarah Gurev; Patrick Varilly; Krithik Ramesh; Nuala A. O'Leary; Jonah Cool; Bernhard Y. Renard; Pardis C. Sabeti; Laura Luebbert

arXiv · 2606.06749

Deterministic access to global viral sequence data enables robust agentic scientific discovery

Ferdous Nasri·Sarah Gurev·Patrick Varilly·Krithik Ramesh·Nuala A. O'Leary·Jonah Cool·Bernhard Y. Renard·Pardis C. Sabeti·Laura Luebbert

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Abstract

Public viral genome resources such as the National Center for Biotechnology Information (NCBI) Virus database are central to outbreak response, evolutionary analysis, vaccine design, and genomic surveillance. Yet many high-value retrieval workflows remain optimized for interactive use rather than deterministic, reproducible programmatic interfaces. This creates a challenge for Large Language Model (LLM)-based scientific agents, where errors in metadata interpretation, filtering logic, or retrieval can propagate into incorrect datasets. To evaluate agentic viral data retrieval, we built VirBench, a manually curated benchmark of 120 queries spanning diverse pathogens, taxonomic levels, and metadata filters. When autonomous AI systems, including Biomni, Claude, GPT, and Edison Analysis, were tasked with these queries without a dedicated retrieval layer, performance varied widely: mean accuracy ranged from 16.9% for Claude Sonnet 4 to 91.3% for GPT-5.5, with newer frontier models showing progress but residual errors remaining consequential. To address this, we built gget virus, a deterministic query framework that formalizes NCBI Virus-style filtering as a reproducible programmatic system. By staging retrieval, applying metadata constraints before sequence download, and retrieving structured GenBank records, gget virus reduces data transfer by more than 98% for high-volume queries while preserving exact-match semantics. Instructing autonomous AI systems to use gget virus increased accuracy to at least 90.0% across all evaluated systems and up to 99.7% for GPT-5.5, improved response stability to 0.92-1.00, reduced error magnitude, and generally decreased runtime and tool calls. Together, this work establishes deterministic data access as critical infrastructure for reliable agentic science and provides a reproducible retrieval layer for robust human- and AI-driven viral genomics workflows.

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Ferdous Nasri, Sarah Gurev, Patrick Varilly, Krithik Ramesh, Nuala A. O'Leary, Jonah Cool, Bernhard Y. Renard, Pardis C. Sabeti, Laura Luebbert. 2026-06-04. Deterministic access to global viral sequence data enables robust agentic scientific discovery. https://arxiv.org/abs/2606.06749

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