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arXiv · 2606.18215

A benchmark suite of intracellular Boolean model variants and multiscale simulations for computational biology

Marco Masera·Riccardo Smeriglio·Roberta Bardini·Alessandro Savino·Stefano Di Carlo
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Abstract

We present PhysiBench, an open resource for developing and evaluating computational methods in systems biology including a benchmark suite of 612 executable intracellular Boolean regulatory network variants and a dataset of 120,000 time-resolved multiscale stochastic simulations. The benchmark models are derived from seven published Boolean networks spanning cell-cycle control, developmental patterning, cancer signaling, immune response, and cell-fate decisions, and are executable in the PhysiBoSS/PhysiCell multiscale simulation framework. Model variants are generated through mutation-based model construction, online behavioral filtering, and offline sensitivity evaluation. The simulation dataset is produced from 60 selected models under systematically sampled stimulation protocols and fixed model-level initial configurations. Each trajectory is linked to its model identifier, input-parameter file, stochastic seed, and cell-level output file. PhysiBench supports direct simulation, surrogate modeling, data-driven inference, simulation-based optimization, and comparative benchmarking. Technical validation includes file-integrity and executability checks, graph-based structural diversity analyses, and behavioral heterogeneity assessment from multiscale simulation outputs.

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Marco Masera, Riccardo Smeriglio, Roberta Bardini, Alessandro Savino, Stefano Di Carlo. 2026-06-16. A benchmark suite of intracellular Boolean model variants and multiscale simulations for computational biology. https://arxiv.org/abs/2606.18215

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