Searcharxiv⌕ Search
Home/Archive/arXiv

arXiv · 2606.29655

Geometric Reliability of Neural Population Codes: Sampling Calibration and Within-Session Nonstationarity

Prashant C. Raju
View original source ↗Read source document ↗Export metadata ↓

Abstract

Trial-to-trial variability limits how reliably neural population geometry can be estimated, while comparisons across populations depend on neuron and trial counts, response quality, and clustered sampling. We quantified within-session geometric reliability using Shesha, the Spearman correlation between representational dissimilarity matrices estimated from independent trial subsets, in all 39 Steinmetz Neuropixels sessions and in olfactory bulb and piriform cortex recordings from Bolding and Franks. Steinmetz analyses matched neurons and repetitions, compared observed reliability with a stationary residual-bootstrap expectation, and used mouse-level or mouse-clustered inference. Mean matched reliability was 0.0402 across 312 area-by-session recordings. Regional differences and reliability above the stationary benchmark did not survive correction. Temporal effects received the strongest support: interleaving early and late trials increased reliability relative to blocked allocation ($Δ=0.02666$, $q=0.001953$), and RDM similarity declined with within-session lag (mean mouse-level slope $=-0.01912$, $q=0.001953$; $n=10$ mice). Outer-cross-fitted reliability was not associated with choice-direction coupling or stimulus or response-direction decoding after correction. Olfactory comparisons remained descriptive because few paired sessions and no animal identities were available. In held-out simulations, associative recurrence outperformed feedforward subspace denoising but not divisive normalization. Representational geometry became less reproducible with temporal separation within a session, and comparisons across neural populations require sampling calibration and independent inference.

Explore related subjects

q-bio.NCcs.NEq-bio.QM

Keep this discovery

BibTeXRIS

Prashant C. Raju. 2026-09-07. Geometric Reliability of Neural Population Codes: Sampling Calibration and Within-Session Nonstationarity. https://arxiv.org/abs/2606.29655

Cite the original work for its findings. Save a collection to share your selection of sources.

Discover connections

cs.NE subjectq-bio.NC subjectq-bio.QM subject

Connections use source metadata and explicit phrase matches, not verified experimental comparisons.

KEEP EXPLORING

Related papers

arXiv2026

Small Molecule Optimization with Large Language Models

Molecular optimization, the process of designing molecules with desirable properties, represents a critical challenge in drug discovery. The recent advancements in large language models (LLMs) have opened new opportunities for their integration with traditional molecular optimization algorithms to improve performance. In this work, we propose Molecular Language Model powered Evolutionary Algorithm (Mol-E), an evolutionary algorithm that relies on the generative capabilities of LLMs trained on molecules and molecular properties. Scientific Contribution. Mol-E obtains the highest aggregate Top-10 AUC among the comparable full-23-task results considered here, scoring 17.500 in the task-agnostic regime, in which the oracle is treated strictly as a black box, and 20.551 in the task-informed regime, in which the optimizer receives a fixed semantic description of the objective. Mol-E also improves over the evaluated baselines on multi-property optimization with docking against DRD2, MK2, and AChE.

cs.LG↗
arXiv2026

Why shared attention vectors fail: a case for outcome-indexed tuning

Dimensional attention in learning is often implemented as a globally shared attention vector, where each stimulus dimension corresponds to a single scalar. These scalars are learned by models through gradient-descent on error, where predictive features acquire more salience. We show that under multi-outcome learning, where models predict more than one outcome, this shared vector becomes unstable; it collapses to its bounds and prevents the models from learning meaningful attentional tunings for learning and generalization. We address this by introducing an outcome-indexed attentional matrix that converts globally shared attentional tuning into an outcome-indexed representation. We present an analysis of the unstable shared vectors and derive the conditions under which it holds. Empirically, three synthetic experiments benchmark the proposed attention matrices and show that they converge to meaningful representations, something shared attention vectors fail to do. These results suggest that outcome-indexed attentional matrices are a general fix for gradient-based attentional processes, which improves models of learning under multi-outcome conditions.

cs.LG↗
arXiv2026

Memory as an Energy Landscape---Hopfield

This chapter reconstructs the Hopfield network as a physical theory of memory rather than merely an early neural-network algorithm. It begins with the problem as it stood before 1982-threshold logic, Hebbian association, correlation memories, and recurrent binary networks-and isolates what Hopfield's synthesis added: a dynamical definition of content-addressable memory, a symmetric recurrent architecture with a Lyapunov function, a Hebbian embedding of patterns in its couplings, and a physical account of basins, robustness, and graceful degradation. The binary and graded-response energy functions are derived in full, together with the signal-crosstalk decomposition governing pattern stability, the mean-field theory of retrieval at extensive load, and the zero-temperature retrieval spinodal at (alpha 0.138) established by Amit, Gutfreund, and Sompolinsky. The energy-based program is then followed through analog optimization networks, polynomial dense associative memories, exponential interactions, and modern continuous Hopfield updates, including the precise conditions under which the update becomes scaled dot-product attention. Throughout, capacity claims are tied to their disorder ensemble, scaling limit, and success criterion, showing why numerically different storage limits need not conflict. A closing assessment distinguishes established results from surviving principles, assumption-bound limitations, and open problems, treating the Hopfield network as an effective theory whose symmetry, locality, and point-neuron assumptions delimit its biological reach. Fixed-seed numerical experiments expose the mechanisms discussed but do not substitute for analytical results.

cs.NE↗