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arXiv · 2606.31758

Plasmon-Enabled High-Precision Single Molecule Localization Microscopy over an Extended Field of View

Muzzamal I. Shaukat·Carlos E. Rodriguez·M. Suhail Zubairy·Oumeng Zhang
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Abstract

We propose PIFLUX, a single-molecule localization scheme combining deep-subwavelength plasmonic illumination with widefield detection. Interference between counter-propagating gap plasmons and a normally incident optical field generates an illumination pattern whose position can be tuned through the plasmon phase while preserving its spatial period. A Cram\'er-Rao analysis shows PIFLUX reaches few-nanometer precision matching MINFLUX while doubling that of SIMFLUX over a micrometer field of view, and a maximum-likelihood estimator confirms this on a synthetic nuclear pore complex.

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Muzzamal I. Shaukat, Carlos E. Rodriguez, M. Suhail Zubairy, Oumeng Zhang. 2026-06-30. Plasmon-Enabled High-Precision Single Molecule Localization Microscopy over an Extended Field of View. https://arxiv.org/abs/2606.31758

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