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arXiv · 2607.02944

A Precedent-Guided Co-Scientist for Side-Effect-Aware Drug Redesign

Yujin Kim·Charmgil Hong
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Abstract

We propose PRECEDE, a precedent-guided co-scientist for side-effect-aware drug redesign that revises a parent compound to mitigate a specified side effect while preserving therapeutic function. Rather than isolated molecular generation, PRECEDE frames redesign as evidence-grounded reasoning over drug--side-effect associations, biomedical knowledge graphs, and precedents of safety-driven optimization, coordinated by an LLM orchestrator with explicit policies and human-review checkpoints. We position PRECEDE as a human-supervised AI-for-science workflow in which hypotheses remain auditable, falsifiable, and bounded by prior pharmacology.

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Yujin Kim, Charmgil Hong. 2026-07-03. A Precedent-Guided Co-Scientist for Side-Effect-Aware Drug Redesign. https://arxiv.org/abs/2607.02944

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