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arXiv · 2607.08073

Cross-Modal Generative Framework for Signal Translation from Fetal-Maternal Electrocardiograms to Fetal Doppler Waveforms

Tongli Su·Alireza Rafiei·Marly van Assen·Reza Sameni·Gari D. Clifford·Faezeh Marzbanrad·Nasim Katebi
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Abstract

Fetal electrocardiogram (fECG) and Doppler ultrasound provide complementary views of fetal cardiovascular function: fECG captures electrical activity while Doppler reflects mechanical hemodynamics shaped by factors such as placental resistance and vascular compliance. Understanding the recoverable and unrecoverable Doppler components through reconstruction from fECG offers insight into the relative contributions of electrical versus mechanical factors in fetal circulation, thereby informing clinical decisions. In addition, clinical evidence of maternal-fetal cardiac coupling suggests that maternal cardiovascular dynamics may also inform fetal hemodynamics. To computationally model these relationships, we propose a cross-modal generative framework combining dilated convolutions with cross-modal attention to selectively incorporate maternal ECG and self-attention to capture long-range temporal dependencies. Trained on 885 synchronized fetal/maternal ECG and Doppler envelope segments from 39 pregnancies, our model synthesizes Doppler envelopes with power spectral density mean squared error (PSD MSE) of 49.9 +/- 15.8 dB^2 (51% lower than two-channel baseline) and heart-rate error of 4.71 +/- 0.77 bpm (1.5% better than baseline; negligible relative to the 110-160 bpm physiological range). Cross-modal attention yields a 39% PSD MSE reduction over naive dual-channel concatenation, quantifying the contribution of maternal-fetal coupling. Our proposed framework advances computational modeling of the maternal-fetal cardiovascular system by enabling the synthesis of Doppler envelopes from dual-lead ECG. By analysis of both recoverable and residual Doppler components, this approach enables quantification of the purely mechanical contributions to Doppler waveforms -- those not recoverable from electrical recordings -- ultimately facilitating a more comprehensive fetal assessment.

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Tongli Su, Alireza Rafiei, Marly van Assen, Reza Sameni, Gari D. Clifford, Faezeh Marzbanrad, Nasim Katebi. 2026-07-09. Cross-Modal Generative Framework for Signal Translation from Fetal-Maternal Electrocardiograms to Fetal Doppler Waveforms. https://arxiv.org/abs/2607.08073

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