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arXiv · 2607.12198

Designing Hierarchical Hub-and-Spoke Drone-Based Networks for Delivering Time-Sensitive Healthcare Items

Sayed Hamid Hosseini Dolatabadi·Tanveer Hossain Bhuiyan·Bo Zeng·J. Tyler Kennedy·Brian O Neill
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Abstract

Timely distribution of medical items (e.g., whole blood and vaccines) across regional healthcare networks often requires high-volume delivery operations from central facilities (e.g., blood banks) to intermediate regional hospitals, followed by rapid last-mile deliveries to points of injury. Traditional ground-based delivery systems often suffer from limited responsiveness (e.g., traffic congestion) and operational inefficiencies (e.g., blood waste). Leveraging aerial-drone-based delivery systems offers a promising solution for the fast and efficient delivery of time-sensitive medical items across regional healthcare networks. Therefore, we study a hierarchical hub-and-spoke drone-based network for delivering time-sensitive medical items with distinct release and due times to fixed and mobile delivery destinations. We consider a heterogeneous fleet of drones with distinct characteristics (e.g., cost, battery capacity, and speed) and different multi-trip delivery modes. We propose an efficient mixed-integer programming model for location/allocation of mobile delivery destinations, as well as routing and scheduling drones to minimize the total investment and operational costs of the drone delivery network while maintaining the delivery due times. We develop a customized exact solution method integrating problem-specific reformulations and dynamic cutting planes, as well as a fast heuristic algorithm by leveraging a simplified problem variant. Results based on a real-life case study of whole blood delivery data from Pendleton, Oregon, United States, and actual drone flight test data demonstrate that our exact and heuristic solution methods are 31 and 3,375 times faster, respectively, than the Gurobi solver. Results also show that allowing drones to perform multiple trips is 142.8% more cost-efficient than single trips.

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Sayed Hamid Hosseini Dolatabadi, Tanveer Hossain Bhuiyan, Bo Zeng, J. Tyler Kennedy, Brian O Neill. 2026-07-13. Designing Hierarchical Hub-and-Spoke Drone-Based Networks for Delivering Time-Sensitive Healthcare Items. https://arxiv.org/abs/2607.12198

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