MedDiT4SR: Tri-Stream Joint Adaptation of Pre-Trained Diffusion Transformers for Medical Image Super-Resolution

Abstract

Medical image super-resolution (MedSR) requires recovering fine anatomical structures from degraded observations while avoiding unsupported details introduced by generative priors. Large-scale pre-trained multimodal diffusion transformers provide strong visual priors, but their adaptation to MedSR remains non-trivial. In conventional ControlNet-style adaptation, the low-resolution (LR) image is processed as an external condition and injected into the denoising stream through one-way connections. Consequently, LR anatomical evidence cannot be jointly updated with the evolving denoising and semantic representations. We propose MedDiT4SR, a tri-stream adaptation framework that integrates the LR, noisy latent, and text representations into the same multimodal diffusion-transformer blocks. To complement global token interaction, we introduce a Super-Resolution Adapter (SR Adapter) that aggregates scale-dependent local tokens and suppresses interpolation-induced redundancy. We further propose a Semantic Alignment Refiner (SA Refiner) that calibrates local LR responses using prompt-conditioned semantic information. Experiments under both in-domain and within-modality cross-dataset settings demonstrate the effectiveness of adapting large-scale pre-trained DiT models to medical image super-resolution across diverse imaging domains.