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arXiv · 2607.25488

Synthesis of hybrid gold-protein nanobioconjugates with strongly enhanced circular dichroism

Yoann Prado·Victoire Ho·Maud Virolle·Maria Sanz-Paz·Mathieu Mivelle·Souhir Boujday·Michèle Salmain·Guillaume Demesy·Nicolas Bonod·Bruno Gallas
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Abstract

Controlling chiral light-matter interactions with nanophotonics is a powerful strategy for amplifying molecular circular dichroism (CD) beyond its natural limits. Here, we present a plasmonic platform that uses superchiral near fields to amplify the optical activity of biological chromophores. Gold nanoparticles (3.6 nm in diameter) are electrostatically coupled with photosynthetic proteins which results in stable hybrid nanobioconjugates in aqueous solution. The Q-band absorption spectrum of the proteins overlaps with the localized surface plasmon resonance of the gold particles. In the visible region, a combination of numerical simulations and normalized CD measurements reveal an enhancement factor of 3 compared to free proteins. This observation reveals three effects. First, there is a local increase in electromagnetic chirality density in the protein environment. Second, there is an increase in the absorption of the proteins. Third, there is plasmon-induced circular dichroism. Our results quantitatively demonstrate that near-field super-chirality directly modulates biomolecular optical activity. These findings open new avenues for chiroptical nanodevices, biosensing platforms, and light-driven asymmetric photochemistry.

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Yoann Prado, Victoire Ho, Maud Virolle, Maria Sanz-Paz, Mathieu Mivelle, Souhir Boujday, Michèle Salmain, Guillaume Demesy, Nicolas Bonod, Bruno Gallas. 2026-07-28. Synthesis of hybrid gold-protein nanobioconjugates with strongly enhanced circular dichroism. https://arxiv.org/abs/2607.25488

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