An Attention-Guided Global and Local Fusion Framework for Lesion-Focused Image Classification

Abstract

Lesion-focused image classification presents a core analytical challenge, as discriminative signals are often sparse, spatially dispersed, and easily obscured by background noise, while conventional convolutional neural networks (CNNs) process entire images uniformly and may dilute signal relevance. This study hypothesizes that adaptive fusion of global contextual information and lesion-focused local information can improve classification performance compared with using either representation independently. We propose a three-branch, attention-guided deep learning framework built on Densely Connected Convolutional Network-121 (DenseNet-121) to improve feature attribution, interpretability, and classification reliability. The architecture consists of a global branch that learns representations from full images, followed by Gradient-weighted Class Activation Mapping (Grad-CAM) to generate attention maps that highlight prediction-relevant regions and produce masked inputs, and a local branch enhanced with a Convolutional Block Attention Module (CBAM) to extract refined spatial and channel-wise features from these focused regions. An adaptive fusion branch integrates global and local representations by learning instance-specific weights, allowing dynamic prioritization between contextual and localized information. The framework is evaluated on a synthetic Spot Pattern Dataset (SSPD) and three benchmark datasets, including skin lesion, guava leaf, and grape leaf image datasets, where the fusion branch outperformed the individual global and local branches, reaching 97.75% accuracy on the skin lesion dataset and 99.64% on the guava leaf dataset. The results highlight the value of attention-guided architectures in healthcare analytics by improving model transparency, strengthening feature relevance, and supporting more reliable data-driven decision-making in medical image analysis.