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arXiv · 2609.16666

Development of a 4D Cerebral Microvascular Imaging Platform for Mouse Stroke Model

Yoshihisa Kaneko·Moe Kumai·Hiroyuki Igarashi·Daisuke Ando·Kuniyasu Niizuma·Hidenori Endo·Yoshifumi Saijo·Takuro Ishii
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Abstract

In ischemic stroke, changes in cerebral hemodynamics during both the ischemic and reperfusion phases strongly influence stroke outcomes. However, these hemodynamic changes remain incompletely understood. To address this challenge, we devised an imaging platform that enables time-resolved ultrasound microvascular imaging during the experimental induction of ischemia and reperfusion in a mouse model. The platform leverages our previous ultrasound imaging framework combined with continuous mechanical scanning, which acquires whole-brain blood-flow signals within 5 s. The experiments demonstrated that the proposed platform can visualize both local and whole-brain hemodynamic responses to the induction of ischemia and reperfusion, suggesting its potential for rapid and continuous whole-brain hemodynamic assessment in small-animal models.

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Yoshihisa Kaneko, Moe Kumai, Hiroyuki Igarashi, Daisuke Ando, Kuniyasu Niizuma, Hidenori Endo, Yoshifumi Saijo, Takuro Ishii. 2026-09-15. Development of a 4D Cerebral Microvascular Imaging Platform for Mouse Stroke Model. https://arxiv.org/abs/2609.16666

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