Digital confocal imaging in holographic optical coherence tomography at high space-bandwidth product

Abstract

Full-field Fourier-domain optical coherence tomography (FF-FD-OCT) enables rapid volumetric imaging but lacks the confocal gating inherent to point-scanning OCT. By acquiring volumes under multiple oblique illuminations, a digital confocal volume can be synthesized in post-processing, a technique originally developed within the framework of reflection matrix imaging (RMI). Existing implementations, however, are often time-domain, off-axis, or use a Michelson interferometer, which reduces sensitivity, speed and the usable space-bandwidth product (SBP). Here, we present an oblique-illumination FF-FD-OCT system in a Mach-Zehnder configuration. This setup enables optimal use of SBP, providing up to a fourfold increase in effective acquisition throughput. In addition, we pose the scattering and aberrations as an overdetermined system, allowing a closed-form solution of an alternating least squares problem. The resulting iterative optimization is equivalent to the state-of-the-art closed-loop accumulation of single scattering (CLASS) algorithm. We demonstrate the setup and reconstruction method in lens tissue, a PSF phantom, a USAF target, and a model eye. The resulting digital confocal volumes provide locally optimized focusing and detection quality, and show improved resolution and signal-to-noise ratio (SNR) compared to conventional FF-FD-OCT. The technique combines the advantages of FF-FD-OCT and confocal OCT while mitigating the limitations of both approaches.