Searcharxiv⌕ Search

arXiv · 2610.12812

Semiparametric Regression Based on Zero Altered Models

Abstract

We develop a class of semiparametric zero-altered models (ZAMs) for count data, estimated through the generalized method of moments (GMM). The proposed framework extends the utility of ZAMs by allowing for both under- and over-dispersion while preserving support on the entire set of natural numbers. This offers an alternative to other models that can experience computational challenges (e.g. Conway-Maxwell-Poisson) or whose supports can be truncated as functions of the parameter space (e.g. generalized Poisson). By formulating estimation through moment restrictions rather than full likelihood specification, the GMM approach provides substantial robustness against model misspecification. In particular, inference based on likelihood methods for parametric generalized linear models (GLMs), such as those built on Poisson, negative binomial, or related count distributions, can become unreliable when the assumed distributional form is violated, often leading to biased estimates and invalid inference. In contrast, our methodology requires only the first two moments of the distribution, ensuring consistent estimation even when higher-order distributional features are misspecified. We establish the asymptotic properties of the estimators, including consistency and asymptotic normality, under general regularity conditions. The flexibility of the approach is illustrated through both simulated experiments and real-data case studies, demonstrating superior performance relative to popular parametric GLMs, particularly in settings characterized by distributional misspecification. To facilitate practical adoption, we provide accompanying R functions for easy implementation, enabling practitioners to apply the proposed methods in applied settings without requiring bespoke programming.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

Sujit K. Ghosh, Timothy Boakye, Kimberly F. Sellers. 2026-10-08. Semiparametric Regression Based on Zero Altered Models. https://arxiv.org/abs/2610.12812

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related papers

A Moment-assisted Approach for Improving Subsampling-based MLE with Large-scale data

The maximum likelihood estimation is computationally demanding for large datasets, particularly when the likelihood function includes integrals. Subsampling can reduce the computational burden, but it often results in efficiency loss.This paper proposes a moment-assisted subsampling (MAS) method that can improve the estimation efficiency of existing subsampling-based maximum likelihood estimators.The motivation behind this approach stems from the fact that sample moments can be efficiently computed even if the sample size of the whole data set is huge.Through the generalized method of moments, the proposed method incorporates informative sample moments of the whole data. The MAS estimator can be computed rapidly and is asymptotically normal with a smaller asymptotic variance than the corresponding estimator without incorporating sample moments of the whole data. The asymptotic variance of the proposed estimator depends on the specific sample moments incorporated. We derive the optimal moment that minimizes the resulting asymptotic variance in terms of Loewner order. The proposed MAS estimator can achieve the same estimation efficiency as the whole data-based estimator when the optimal moment is incorporated. Numerical results demonstrate the promising performance of the proposed method in both estimation and computational efficiency compared with existing subsampling methods.

stat.ME↗

Active Sequential Signal Detection with Asynchronous Decisions

The problem of quickly detecting signals among multiple sequentially observed data streams, subject to constraints on the familywise false-alarm and missed-detection probabilities, is considered under an active sampling setup where only one stream can be sampled at each time instant. Under this setup, it is in general impossible to minimize, even asymptotically, the expected decision time simultaneously for every stream. We therefore consider minimizing the expected time until either the kth signal declaration or termination simultaneously for every k. We first establish non-asymptotic lower bounds for these criteria. For k > |B|, where B denotes the true subset of signals, we show that these lower bounds are attained asymptotically as the error levels vanish by any policy that stops sampling and makes a decision for each stream according to a local Sequential Probability Ratio Test. For 1 <= k <= |B|, however, the performance depends critically on the sampling rule, and we propose one with a simple exploration mechanism that prevents switching away from signals prematurely because of early unfavorable observations. We show that, under a mild relative-rate condition on the two error levels, the resulting policy attains all the lower bounds simultaneously. Numerical studies are presented to compare the proposed policy with an oracle policy and a follow-the-leader policy.

stat.ME↗

Typical Healthcare Pathways as a Basis for Admixture Modeling of Patient Trajectories

Background: Understanding whether patients follow similar or distinct patterns of care is important for characterizing clinical practice, identifying patient subgroups, and supporting quality improvement. However, routine healthcare trajectories are difficult to compare directly because patients may differ in their diagnostic workup, treatment sequencing, timing of clinical events, and documentation practices. Despite this variation, trajectories often contain recurring patterns at the cohort level. Methods: To address this challenge, we present a framework that explicitly separates cohort-level typical pathway identification from patient-level inference. At the cohort level, we derive an interpretable representation of care processes using a rule-based algorithm to identify typical healthcare pathways, resulting in a compact pathway graph. These pathways are then modeled as Markov chains and used as structured components in an admixture model, allowing each patient to be represented as a probabilistic mixture of typical pathways rather than being assigned to a single pathway component. The resulting admixture weights provide a compact representation of patient trajectories for subgroup characterization. We further assess the stability of the identified pathways and inferred admixture representations across multiple train-test splits. Results: Across train-test splits, the framework demonstrated consistent pathway structures and patient-level mixture patterns. Applied to routine care data from prostate cancer patients undergoing radical prostatectomy, the framework identified interpretable care patterns and supported the identification of patient subgroups with similar clinical event patterns. Conclusion: Overall, the proposed framework provides an interpretable and stable approach for summarizing treatment pathways and characterizing patient subgroups in real-world practice.

stat.ME↗