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arXiv · 2610.23361

Surveying Experimentally-Validated Components for DNA-Based Molecular Communication

Andreas Waldner·Regine Wendt·Nils Stumpf·Sarah Scheer·Christian Hyttrek·Stefan Fischer·Florian-Lennert Lau
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Abstract

Molecular communication is a novel paradigm for the design of nanonetworks. It uses molecules as information carriers and enables communication between nanodevices. DNA-based molecular communication is a promising approach for medical applications, such as in-body networks for diagnostics and drug delivery. However, the transition from theoretical models to practical experiments is still in its early stages. This survey reviews experimentally validated DNA-tiles, nanocarriers, and biosensors relevant to implementing DNA-tile-based nanonetworks in vitro. We evaluate these components based on their stability, compatibility, cost-effectiveness, and overall suitability for wet-lab implementation. Based on this analysis, we identify promising component combinations and derive a blueprint for a minimal proof-of-concept experiment. The resulting framework provides researchers with both a structured overview of experimentally relevant design choices and a concrete starting point for implementing and validating DNA-based nanonetworks in the wet lab.

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Andreas Waldner, Regine Wendt, Nils Stumpf, Sarah Scheer, Christian Hyttrek, Stefan Fischer, Florian-Lennert Lau. 2026-10-16. Surveying Experimentally-Validated Components for DNA-Based Molecular Communication. https://arxiv.org/abs/2610.23361

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