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arXiv · 2611.02671

TME-ContextNet: Class-Conditioned Spatial Supervision and Grouped Decoding for Joint Nuclei Instance Segmentation and Classification

Rukang Ma·Bingxue Wang·Liwen Zou·Yingying Cao·Zhenghua Cai·Yu Li·Dong Wang·Huiyu Zhou·Luying Gui
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Abstract

Joint nuclei instance segmentation and classification requires precise boundaries and neighborhood information that helps distinguish morphologically similar cell types. We present TME-ContextNet, a multi-task framework that learns class-conditioned spatial context from existing nuclear annotations and organizes decoding into geometry-related and semantic task groups. Class-conditioned spatial supervision extends nuclear labels into a dense target using Euclidean distance transforms, requiring no additional tissue-region annotation. We derive its nearest-region interpretation and characterize its stability to small annotation perturbations. A local--global context module combines dilated convolution and self-attention, while a grouped task decoder reduces redundant computation. The spatial head supplies training supervision and is omitted during inference. Experiments on PanMix, CoNSeP, and PanNuke yield Dice scores of 80.23%, 65.32%, and 79.13%, and mean multi-class panoptic quality (mPQ+) scores of 58.67%, 35.50%, and 43.74%, respectively. PanNuke results are averaged across three test folds. Target and decoder controls support the combination of distance-based supervision and grouped decoding while identifying their dependence on task configuration. The framework uses 36.40 million parameters, compared with 54.74 million for HoVer-Net. These findings support a compact, context-aware formulation for joint nuclei analysis in computational pathology.

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Rukang Ma, Bingxue Wang, Liwen Zou, Yingying Cao, Zhenghua Cai, Yu Li, Dong Wang, Huiyu Zhou, Luying Gui. 2026-11-03. TME-ContextNet: Class-Conditioned Spatial Supervision and Grouped Decoding for Joint Nuclei Instance Segmentation and Classification. https://arxiv.org/abs/2611.02671

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