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A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties

M-T. Kechadi·R. G. Reilly·K. A. Dawson·Yu. A. Kuznetsov·E. G. Timoshenko
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Abstract

In this paper we present a method to study the folding structure of a simple model consisting of two kinds of monomers, hydrophobic and hydrophilic. This method has three main steps: an efficient simulation method to bring an open sequence of homopolymer to a folded state, the application of a painting method called (regular hull) to the folded globule and the refolding process of the obtained copolymer sequence. This study allows us to suggest a theoretical function of disorder distribution for copolymer sequences that give rise to a compacted and well micro-phase separated globule.

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M-T. Kechadi, R. G. Reilly, K. A. Dawson, Yu. A. Kuznetsov, E. G. Timoshenko. 2001-04-23. A Study of Sequence Distribution of a Painted Globule as a Model for Proteins with Good Folding Properties. https://arxiv.org/abs/cond-mat/0104440

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