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A Cooperative Stochastic Model of Gene Expression

Siddhartha Roy·Indrani Bose·Subhrangshu Sekhar Manna
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Abstract

Recent experiments at the level of a single cell have shown that gene expression occurs in abrupt stochastic bursts. Further, in an ensemble of cells, the levels of proteins produced have a bimodal distribution. In a large fraction of cells, the gene expression is either off or has a high value. We propose a stochastic model of gene expression the essential features of which are stochasticity and cooperative binding of RNA polymerase. The model can reproduce the bimodal behaviour seen in experiments.

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Siddhartha Roy, Indrani Bose, Subhrangshu Sekhar Manna. 2001-05-11. A Cooperative Stochastic Model of Gene Expression. https://doi.org/10.1142/s0129183101001821

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